Incidence of prostatic intraepithelial neoplasia in TURP specimens with special reference to p63 expression in various lesions of prostate

Introduction: Prostate cancer is the second common malignancy in men. Prostatic intraepithelial neoplasia (PIN) precursor lesion of prostatic carcinoma. Histopathological examination necessary to diagnose PIN lesions. Objective: The aim study determine incidence and analyse usefulness basal cell marker p63 expression various lesions prostate. Methods: This a two-year prospective 65 transurethral resection specimens prostate, carried out Department pathology, Dr B R Ambedkar Medical College, Bangalore. mmunohistochemical used its was analysed. Results: Out cases studied, 4 were inflammatory lesions, 52 benign hyperplasia (BPH) 9 malignant Low grade identified 8(12.3%) BPH. High seen 9(13.8%) tufting pattern commonest. HGPIN predominantly associated with adenocarcinoma. expressed all glands BPH HGPIN. Malignant negative for expression.